AUTHOR=Jawoosh Muhammad , Zayat Rashad , Dogan Leyla , Shieba Yusuf , Moza Ajay , Tewarie Lachmandath , Lotfi Shahram , Khattab Mohammad Amen , Abugameh Ahmad , Mohammed Ahmed F. A. 

TITLE=Sex-related differences in prosthesis-patient mismatch following aortic valve replacement with the edwards intuity valve system

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1666443

DOI=10.3389/fcvm.2025.1666443

ISSN=2297-055X

ABSTRACT=BackgroundProsthesis-patient mismatch (PPM) is linked to a poor prognosis following surgical aortic valve replacement (SAVR). The exploration of sex differences in PPM outcomes is currently limited. This study seeks to assess the sex-specific effects of PPM following SAVR was rapid deployment AV (RDAVR) prosthesis the Edwards Intuity.MethodsFrom 2018 to 2023, a total of 256 patients (60 females and 196 males) who received isolated or combined RDAVR at our institution were included. The definition of PPM was established through the use of the indexed effective orifice area (EOAi) in accordance with the Valve Academic Research Consortium-3 (VARC-3) criteria. A Multivariate logistic regression was performed to identify predictors of any degree PPM.ResultsFemale had higher left ventricular ejection fraction preoperatively (p = 0.018). The incidence of any PPM-degree for patients with BMI <30 kg/cm2 was significantly higher in female than in male [33 (55%) vs. 26(13.3%), p < 0.001]. The same was noted for the incidence of PPM in patients with BMI ≥30 kg/cm2 [7 (11.7%) vs. 4 (2.0%), p = 0.004]. And the incidence of severe PPM (EOAi ≤0.65 cm2/m2) for patients with BMI <30 kg/cm2 was 16.7% in females vs. 0 in males (p < 0.001). The in-hospital mortality did not differ between males and females. In the multivariate logistic regression, we could not identify independent predictors of PPM.ConclusionsIn Patients receiving RDAVR, the incidence of PPM was significantly higher in female than in male. However, we did not find a correlation with early clinical outcomes. The incidence of severe PPM after RDAVR was low in both females and males. Due to differences in geometry and function of the LV in women, further studies are necessary to indicate whether the definition of PPM in men may adhere to elevated EOAi thresholds compared to women.