CASE REPORT article

Front. Cardiovasc. Med., 22 July 2026

Sec. Cardiovascular Surgery

Volume 13 - 2026 | https://doi.org/10.3389/fcvm.2026.1840464

Aortoileal fistula following endovascular repair of an abdominal aortic aneurysm: a case report

  • Department of Vascular Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China

Abstract

Introduction:

Aortoenteric fistula (AEF) following endovascular aortic repair (EVAR) for abdominal aortic aneurysm (AAA) is a rare but severe complication, with most reported cases involving the duodenum, and involvement of the ileum is exceptionally uncommon.

Case presentation:

We report a rare case of secondary aortoileal fistula with concomitant graft infection in a 66-year-old male, occurring two years after EVAR for AAA. The follow-up imaging 2 years after EVAR showed no aneurysmal sac regression, suggestive of a type II endoleak, which was treated with coil embolization. One week post-embolization, the patient presented with abdominal pain and fever, and a secondary aortoileal fistula was diagnosed. The patient underwent bilateral axillofemoral bypass, excision of the AAA and endograft, and intestinal perforation repair. Intraoperative cultures grew Lactobacillus paracasei. The patient recovered uneventfully and remained well at 1-year follow-up.

Conclusion:

Aortoileal fistula after EVAR for AAA is an extremely rare yet potentially fatal complication and should be recognized by both clinicians and patients. It may occur as early as 1 month post-operatively or even more than 10 years after EVAR. Appropriate surgical management should be considered on an individual basis to achieve favorable outcomes.

1 Introduction

Aortoenteric fistula (AEF) is a rare but life-threatening complication and can be classified as primary or secondary AEF. Secondary AEF denotes an AEF that develops after surgical repair of an aortic aneurysm. Most secondary AEFs occur after open abdominal aortic reconstruction (1). AEF following endovascular abdominal aortic aneurysm repair (EVAR) is quite uncommon, with an incidence ranging from approximately 0.26%–3.66% (2–4). The vast majority of fistulas involve the duodenum, whereas those affecting other segments of the small intestine or the colon are exceedingly rare (5). The reported in-hospital mortality rate for patients who developed AEF after EVAR is 22% (4), while the perioperative mortality for those treated with endovascular repair is approximately 37% (6). However, mortality approaches 100% in patients who do not undergo timely or feasible surgical intervention (7, 8).

We report the case of a 66-year-old man who underwent EVAR for an abdominal aortic aneurysm (AAA) and subsequently developed an aortoileal fistula 2 years after the procedure. The fistula occurred in the ileum rather than the more commonly involved duodenum. The patient was treated with axillo-bifemoral bypass, graft explantation, and ileal repair and remained alive at the 1-year follow-up (Figure 1).

Figure 1

2 Case description

On September 12, 2022, a 66-year-old male was found to have an AAA during a health check-up, with no significant presenting symptoms or complaints. Abdominal computed tomography angiography (CTA) showed aneurysmal dilatation of the infrarenal abdominal aortic lumen with a maximum diameter of approximately 77 mm (Figures 2A,B). He subsequently underwent EVAR using a bifurcated covered stent graft (main body: Gore Excluder, 28 × 14 × 180 mm; iliac limbs: Gore, 16 × 12 × 140 mm, 16 × 12 × 180 mm, and 16 × 14 × 100 mm), bilateral common iliac artery stent implantation, and embolization of the right internal iliac artery with coils (Cook, sizes 10 mm, 16 mm, and 4 mm). Intraoperative angiography demonstrated a proximal type Ia endoleak; despite balloon dilation at the graft junction, a small amount of proximal endoleak persisted, while both iliac arteries opacified well. Postoperative surveillance imaging was therefore planned and conducted at regular intervals.

Figure 2

On January 28, 2023, CTA demonstrated a circumferential low-attenuation rim around the stent graft, with a maximum diameter of approximately 91 mm (Figures 2C,D). The aneurysm sac appeared slightly larger than before surgery, but no obvious contrast filling was observed. The patient had no significant complaints, so continued close observation was recommended.

In October 2024, the patient developed low back pain without fever, chills, or other discomfort. CTA showed enlargement of the aneurysm sac to a diameter of 11 cm. Angiography suggested localized accumulation of contrast medium around the graft, suggestive of a possible type II endoleak (external hospital data unavailable for provision). On December 20, 2024, he underwent embolization of an internal iliac artery branch endoleak, after which his back pain was relieved. One week later, the patient again developed low back pain accompanied by fever (maximum temperature 38.2 °C) and was subsequently transferred to our hospital for further management.

After transmission, CTA showed postoperative changes following EVAR with covered stent graft and iliac artery balloon angioplasty, with multiple gas shadows within the original aneurysmal sac (Figure 2E), raising concern for an internal fistula with the small intestine. Laboratory tests showed elevated C-reactive protein (CRP; 184 mg/L), interleukin-6 (IL-6, 232 pg/mL), and erythrocyte sedimentation rate, with mild anemia (hemoglobin, 93 g/L), positive fecal occult blood testing, and an elevated D-dimer level. Blood cultures were negative for bacteria and fungi. Combining all the examinations, secondary AEF and graft infection were highly suspected. Surgical intervention was therefore undertaken. First, bilateral axillofemoral bypass using prosthetic grafts was performed. Upon completion, exploratory laparotomy revealed an ulcerative lesion of the ileum approximately 260 cm distal to the ligament of Treitz, adherent to the abdominal aortic lesion (Figure 2F). The AAA measured approximately 8 cm × 8 cm; the lumen was rigid, with no obvious pulsation observed. The aneurysm was then excised, and the endograft was removed (Figure 2G).

Postoperatively, the patient was transferred to the intensive care unit. He was extubated on postoperative day 1 and, with stable vital signs, was transferred to the general ward. Intraoperative cultures of infected tissue grew Lactobacillus paracasei. Based on susceptibility testing, vancomycin and linezolid were administered, and anticoagulation with warfarin was initiated. CTA of the entire aorta at discharge showed patent bypass grafts and no evidence of leakage from the residual stumps of the abdominal aorta and bilateral iliac arteries (Figure 2H). Concomitant pyogenic osteomyelitis was diagnosed; orthopedic consultation recommended continuation of antimicrobial therapy and lumbar immobilization with a brace. The patient was discharged in good condition 2 weeks after surgery. At the 12-month follow-up, the patient had a favorable outcome.

3 Discussion

AEF after EVAR is rare (incidence 0.26%–3.66%) but life-threatening. Although the duodenum is the most commonly involved site, fistulas affecting the jejunum (9), ileum, or colon (10) are exceedingly rare. To our knowledge, this is the first reported case of aortoileal fistula after EVAR, bringing the total number of cases with detailed patient-level data in the English literature to 43 (Table 1). These cases demonstrate marked male predominance (90.48%), with a mean age of 71.7 years and a median interval from EVAR to AEF of 18 months (range 1–180 months) (Table 2).

Table 1

DateAuthorAge/SexClinical presentationPerioda (months)Treatment for secondary AEFOutcomeEstimated etiology
2026Prent66/MBack pain, fever27Endograft explant, extra-anatomic revascularization, bowel repairAlive at 12 monthsEndoleak
2025Romanowska et al.68/MMelena and fatigue92Abdominal drainage and antibioticDiedEndoleak
2023Oka et al.86/MMalaise and melena12Endograft explant, in situ reconstruction and bowel repairDied after 4 weeksIgG4-related periaortitis
2022White et al.69/MBack pain, melena, fever36Endograft explant, extra-anatomic revascularization, bowel repairAlive at 3 monthsUnknow
2022Li et al.71/MHematemesis, melena, fever6Endograft explant, in situ reconstruction and bowel repairAlive at 6 monthsUnknow
2021Moriyama et al.70/MFever24Endograft explant, in situ reconstruction and bowel repairAlive at 35 monthsUnknow
2021Joshi et al.80/MFever, chills and melena2Only bowel repairAlive at 9 monthsUnknow
2021Gunawardena et al.73/Melena, fever39Endograft explant, extra-anatomic revascularization, bowel repairDied after 12 daysType II endoleak.
2021Hassan et al.65/MHemorrhage of digestive tract24Endograft explant, in situ reconstruction and bowel repairAlive at 2 monthsUnknow
2020Nguyen et al.85/FAbdominal pain25Endograft explant, extra-anatomic revascularization, bowel repairAlive at 24 monthsUnknow
2020Hosaka et al.79/MFever and melena15Endograft explant, in situ reconstruction and bowel repairDied after 25 monthsUnknow
2020Hosaka et al.71/MBack pain58Endograft explant, in situ reconstruction and bowel repairAlive at 69 monthsType II endoleak
2020Hosaka et al.76/MAnorexia and back pain74Endograft explant, in situ reconstruction and bowel repairAlive at 53 monthsType II endoleak
2020Hosaka et al.81/MChest pain and melena15Endograft explant, in situ reconstruction and bowel repairAlive at 46 monthsType II endoleak
2019Walter et al.75/MFever, abdominal pain48Endograft explant, in situ reconstruction and bowel repairAlive at 5 monthsUnknow
2018Wang et al.87/MMelena, fevers20Abdominal drainage and antibioticAlive at 23 monthsUnknow
2018Arworn et al.43/MHematemesis and melaena13Endograft explant, extra-anatomic revascularization, bowel repairAlive at 9 monthsBehcet's disease
2018Jiang et al.85/MMelena, tiredness, fever30Endograft explant, extra-anatomic revascularization, bowel repairAlive at 15 monthsUnknow
2016Gülcü et al.72/MSeptic syndrome14Endograft explant, extra-anatomic revascularization, bowel repairUnclearFungal infection
2016Kadhim et al.66/MConfusion, fever180Bowel repairAlive at 12 monthsInfection
2014Zaki et al.75/MAbdominal pain, hematemesis6Intraoperative deathIntraoperative deathUnknow
2014Sörelius et al.58/MAbdominal pain, fever30Endograft explant, extra-anatomic revascularization, bowel repairAlive at 48 monthsStent graft had kinked
2014Kasashima et al.79/MAbdominal pain, melaena4NoneDiedIgG4-related periaortitis
2013Zhang et al.65/MFever38Endograft explant, extra-anatomic revascularization, bowel repairAlive at 1 monthsUnknow
2012Veraldi et al.71/MMelaena, lipothymia72Endograft explant, in situ reconstruction and bowel repairAlive at 12 monthsUnknow
2012Kao et al.82/MBloody diarrhea3Endograft explant, extra-anatomic revascularization, bowel repairDied after 2 daysUnknow
2011McPhee et al.88/FNausea, dizziness48Endograft explant, extra-anatomic revascularization, bowel repairAlive at 5 monthsType II endoleak
2009Tromp et al.68/MSymptom free1Endograft explant, in situ reconstruction and bowel repairAlive at 6 monthsEndoleak
2009Lane et al.69/MFever, chills, lethargy, diarrhea6Endograft explant, extra-anatomic revascularization, bowel repairAlive at 2 weeksUnknow
2009Chenu et al.67/MFever and lumbar pain14Endograft explant, in situ reconstruction and bowel repairAlive at 2 monthsUnknow
2007Ruby et al.80/MAbdominal pain, nausea58Endograft explant, in situ reconstruction and bowel repairAlive at 13 monthsUnknow
2006Ghosh et al.52/MAbdominal and back pain, hemat-emesis9NoneDied after 1 daysStent-graft infection
2004French et al.69/FDigestive hemorrhage16Endograft explant, extra-anatomic revascularization, bowel repairDied at 6 daysStent-graft infection
2003AbouZamzam et al.67/MAbdominal pain11Endograft explant, extra-anatomic revascularization, bowel repairAlive at 4 monthsUnknown endotension?
2003Bertges et al.78/MInfection, vomiting53Endograft explant, extra-anatomic revascularization, bowel repairAlive at 1 monthEndoleak coil
2003Elkouri et al.78/FHematemesis and melena17Endograft explant, extra-anatomic revascularization, bowel repairDied at 12 hEndoleak coil
2003Alankar et al.76/MAbdominal pain, hematochezia4Endograft explant, in situ reconstruction and bowel repairAlive at 6 monthsType I endovascular leak
2002Kar et al.78/MFever, malaise20Endograft explant, in situ reconstruction and bowel repairAlive at 1 yearUnknown endotension?
2001Parry et al.61/MDigestive hemorrhage6Endograft explant, in situ reconstruction and bowel repairAlive at 7 monthsPeri-aortic inflammatory mass
2000Makar et al.70/MAbdominal pain, fever, digestive hemorrhage4Antibiotic onlyDiedCrohn's disease
2000Janne et al.62/MDigestive hemorrhage, infection22Endograft explant, extra-anatomic revascularization, bowel repairAlive at 40 monthsMigrated and kinked stent graft
1999Hausegger et al.53/MAbdominal pain, digestive hemorrhage18Endograft explant, in situ reconstruction and bowel repairAlive at 6 monthsMigrated and kinked stent graft
1998Norgren et al.71/MAbdominal pain, digestive hemorrhage17Endograft explant, in situ reconstruction and bowel repairAlive at 6 monthsPeri-aortic inflammatory mass and ruptured graft

Aorto-enteric fistulas after EVAR in English literature.

a

Period: Time after EVAR; F, female; M, male.

Table 2

Characteristicsn (%) or mean ± SD (range)
Age (year) (n = 43)
 Mean71.7 ± 9.62 (43–88)
 Sex (male/female), (male %) (n = 42)38/4 (90.48%)
Location of intestinal fistula (n = 43)
 Duodenum40 (93.02%)
 Jejunum1 (2.33%)
 Ileum1 (2.33%)
 Colon1 (2.33%)
 Time after EVAR (months)28.63 ± 32.00 (1–180)
Vascular reconstruction (n = 36)
 In situ reconstruction19 (52.78%)
 Extra-anatomic revascularization17 (47.22%)
 Overall mortality rate (n = 42)11/42 (26.19%)
 Mortality rate of surgical patients6/36 (16.67%)
 Mortality rate of nonsurgical patients4/5 (80.00%)
 Number of intraoperative deaths1

Summary of data from all 43 cases of AEF after EVAR in the English literature.

The pathogenesis of post-EVAR AEF is multifactorial. Established mechanisms include mechanical erosion by the stent graft, endograft migration or kinking (11), barbs/hooks injury (12), and persistent aneurysm sac pressurization due to endoleak or endotension (13). Type II endoleak is the most frequently reported cause of secondary enteric fistulization after EVAR (14). Additionally, coils left in situ after endoleak embolization may cause delayed bowel erosion (15). Other rare contributing factors include IgG4-related periaortitis and underlying inflammatory bowel disease (16). In the present case, a type II endoleak was identified and treated with coil embolization, followed by symptom onset only 7 days later. In contrast to the typically delayed presentations (months to years), this short interval raises the possibility that the embolization procedure itself may have accelerated fistula formation through local mechanical irritation, coil migration, or induction of inflammation. Rapid sac enlargement (from 9.1 cm to 11 cm) also occurred prior to fistula diagnosis. We hypothesize that coil embolization, particularly when followed by rapid sac enlargement, may convert a low-grade chronic inflammatory state into an acute fistulogenic process through localized ischemia, foreign body reaction, or micro-perforation, beyond simple mechanical erosion.

The ileal involvement is noteworthy, as the ileum is mobile and usually distant from the graft. Intraoperative adherence between the ileal lesion and aortic sac suggests that periaortic adhesions combined with chronic inflammation and sac expansion enabled fistula formation at this unexpected site.

Clinically, AEF presents with nonspecific symptoms. In this patient, recurrent low back pain and fever were prominent, associated with vertebral osteomyelitis. Key early warning signs include rapid sac enlargement, persistent back pain, perigraft gas/fluid on CT, and elevated inflammatory markers. These should prompt urgent evaluation for graft infection or AEF. Differential diagnoses include type II/III endoleak, endotension, graft infection, and post-interventional inflammation. Contrast-enhanced CT is the first-line imaging modality.

Management remains challenging. In the 43-case analysis, overall mortality was 26.19% (11/42) (17), with markedly higher rates in non-operatively managed patients (60% in-hospital) (18, 19). The 2016 AHA scientific statement recommends extra-anatomic revascularization for typical cases, while in situ reconstruction may be considered in selected low-risk patients (20). Among the 43 post-EVAR AEF cases, 36 underwent open surgery: 17 had extra-anatomic revascularization (e.g., axillofemoral bypass with graft excision and debridement), which eradicates infection but risks stump blowout, longer operative time, and greater trauma. The other 19 had in situ reconstruction, which is more anatomical, avoids stump rupture and additional incisions, and lowers amputation risk (21). Conduits include biologic or nonbiologic materials (22, 23), and omental flap coverage may facilitate infection control (24). No significant differences in mortality or infection-related complications have been shown between the two approaches (25), but in situ reconstruction should be avoided with extensive purulent peritoneal contamination. In emergencies (e.g., hemodynamic instability, massive hemorrhage, or poor surgical tolerance), endovascular therapy can serve as a temporizing measure (5), as one retrospective study found better perioperative survival with stent-grafts for life-threatening bleeding than with open surgery (5). In the present case, the patient underwent bilateral axillofemoral bypass, graft explantation, and primary ileal repair. For ileal fistulas, intestinal repair is generally straightforward compared with duodenal fistulas.

Culture-directed antibiotic therapy is mandatory. Intraoperative tissue yielded Lactobacillus paracasei; although often considered a commensal, its isolation in pure culture from periaortic tissue in the context of enteric fistula supports its role as a true enteric pathogen. We recommend at least 6–8 weeks of intravenous antibiotics followed by oral therapy, tailored to clinical response. Lifelong suppression may be required in cases of incomplete graft removal or highly virulent organisms (14).

This case provides several actionable insights for clinical practice. First, recent coil embolization for type II endoleak warrants close surveillance for accelerated AEF, particularly if new back pain or rapid sac enlargement develops. Second, sac enlargement and recurrent back pain are critical warning symptoms that should prompt early CTA or endoscopy. Third, AEF may involve mobile bowel segments such as the ileum when periaortic adhesions are present, emphasizing the need for thorough imaging and intraoperative inspection of all adherent bowel loops. Finally, timely extra-anatomic revascularization combined with graft removal can achieve favorable outcomes when fistula location allows simpler bowel repair.

4 Conclusion

Aortoileal fistula after EVAR for AAA is an extremely rare yet potentially fatal complication and should be recognized by both clinicians and patients. It may occur as early as 1 month post-operatively or even more than 10 years after EVAR; therefore, lifelong follow-up is needed. Once the diagnosis is established, in addition to antibiotic therapy, appropriate surgical management should be considered on an individual basis to achieve favorable outcomes.

5 Limitations

This study has several limitations. As a single case report, the findings may not be generalizable to broader patient populations. The precise mechanism of aortoileal fistula formation in this patient remains speculative due to the complex interplay of potential contributing factors, including type II endoleak, coil erosion, and possible inflammatory processes. Additionally, long-term outcomes beyond one year of follow-up are not available, limiting assessment of the durability of the surgical treatment.

6 Highlights

  • AEF following EVAR for AAA is a rare but severe complication.

  • Most reported AEF cases involved the duodenum.

  • Aortoileal fistula is exceptionally uncommon.

  • We report a case of aortoileal fistula with successful surgical management.

  • Lifelong follow-up is necessary to AEF patients.

Statements

Data availability statement

The raw data supporting this case report are available from the corresponding author upon reasonable request.

Ethics statement

The studies involving humans were approved by The Ethics Committee of the Second Affiliated Hospital, Zhejiang University School of Medicine. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.

Author contributions

YF: Writing – original draft, Writing – review & editing. YP: Project administration, Resources, Writing – original draft. HZ: Funding acquisition, Methodology, Writing – original draft. XM: Data curation, Software, Writing – original draft. JW: Supervision, Validation, Writing – review & editing. BC: Writing – review & editing, Conceptualization, Supervision, Writing – original draft.

Funding

The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the Natural Science Foundation of Zhejiang Province, China, No. LQ21H020007.

Acknowledgments

We are thankful to the patients and all the physicians and technicians who participated in this case. We also appreciate the language editing service of Editgy.

Conflict of interest

The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Generative AI statement

The author(s) declared that generative AI was not used in the creation of this manuscript.

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Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Supplementary material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fcvm.2026.1840464/full#supplementary-material

Abbreviations

AEF, Aortoenteric fistula; EVAR, endovascular aortic repair; AAA, abdominal aortic aneurysm; CTA, computed tomography angiography; AHA, American Heart Association.

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Summary

Keywords

abdominal aortic aneurysm, aortoenteric fistula, aortoileal fistula, case report, endovascular abdominal aortic aneurysm repair

Citation

Feng Y, Pan Y, Zhou H, Meng X, Wang J and Chen B (2026) Aortoileal fistula following endovascular repair of an abdominal aortic aneurysm: a case report. Front. Cardiovasc. Med. 13:1840464. doi: 10.3389/fcvm.2026.1840464

Received

27 March 2026

Revised

22 June 2026

Accepted

26 June 2026

Published

22 July 2026

Volume

13 - 2026

Edited by

Ayman Elbadawi, University of Texas Medical Branch at Galveston, United States

Reviewed by

Halil Ibrahim Altunbulak, Bitlis Tatvan State Hospital, Türkiye

Daijirou Akamatsu, Osaki Citizen Hospital, Japan

Mohamed Hamed, Florida Atlantic University, United States

Updates

Copyright

*Correspondence: Bing Chen

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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