AUTHOR=Jablonska Agnieszka , Polouliakh Natalia TITLE=In silico discovery of novel transcription factors regulated by mTOR-pathway activities JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=Volume 2 - 2014 YEAR=2014 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2014.00023 DOI=10.3389/fcell.2014.00023 ISSN=2296-634X ABSTRACT=

The mammalian target of rapamycine (mTOR) pathway is a key regulator of cellular growth, development, and ageing, and unraveling its control is essential for understanding life and death of biological organisms. A motif-discovery workbench including nine tools was used to identify transcription factors involved in five basic (Insulin, MAPK, VEGF, Hypoxia, and mTOR core) activities of the mTOR pathway. Discovered transcription factors are classified as “process-specific” or “pathway-ubiquitous” with highlights toward their regulating/regulated activities within the mTOR pathway. Our transcription regulation results will facilitate further research on investigating the control mechanism in mTOR pathway.