AUTHOR=Li Ming , Guo Kuquan , Ikehara Susumu 

TITLE=Intractable diseases treated with intra-bone marrow-bone marrow transplantation

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 2 - 2014

YEAR=2014

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2014.00048

DOI=10.3389/fcell.2014.00048

ISSN=2296-634X

ABSTRACT=Bone marrow transplantation (BMT) is used to treat hematological disorders, autoimmune diseases and lymphoid cancers. Intra bone marrow-BMT (IBM-BMT) has been proven to be a powerful strategy for allogeneic BMT due to the rapid hematopoietic recovery and the complete restoration of T cell functions. IBM-BMT not only replaces hematopoietic stem cells but also mesenchymal stem cells (MSMCs). MSMCs are multi-potent stem cells that can be isolated from bone marrow, umbilical cord blood, and adipose tissue. MSMCs play an important role in the support of hematopoiesis, and modify and influence the innate and adaptive immune systems. MSMCs also differentiate into mesodermal, endodermal and ectodermal lineage cells to repair tissues. This review aims to summarize the functions of bone marrow-derived- MSMCs, and the treatment of intractable diseases such as rheumatoid arthritis and malignant tumors with IBM-BMT.