AUTHOR=Du Xingrong , Chapman Nicole M. , Chi Hongbo 

TITLE=Emerging Roles of Cellular Metabolism in Regulating Dendritic Cell Subsets and Function

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 6 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2018.00152

DOI=10.3389/fcell.2018.00152

ISSN=2296-634X

ABSTRACT=Dendritic cells (DCs) function as the bridge between innate and adaptive immunity and potently prime T cell activation. Recent studies have identified critical roles of metabolic pathways in orchestrating DC function. Understanding the metabolic basis of DC functional specification and regulation has the great potential to facilitate DC-based immunotherapy. In this review, we discuss the recent progress regarding the cellular metabolism in programming the function of different DC subsets in mice.