AUTHOR=Wu Selwin K. , Priya Rashmi TITLE=Spatio-Temporal Regulation of RhoGTPases Signaling by Myosin II JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=Volume 7 - 2019 YEAR=2019 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2019.00090 DOI=10.3389/fcell.2019.00090 ISSN=2296-634X ABSTRACT=

RhoGTPase activation of non-muscle myosin II regulates cell division, extrusion, adhesion, migration, and tissue morphogenesis. However, the regulation of myosin II and mechanotransduction is not straightforward. Increasingly, the role of myosin II on the feedback regulation of RhoGTPase signaling is emerging. Indeed, myosin II controls RhoGTPase signaling through multiple mechanisms, namely contractility driven advection, scaffolding, and sequestration of signaling molecules. Here we discuss these mechanisms by which myosin II regulates RhoGTPase signaling in cell adhesion, migration, and tissue morphogenesis.