AUTHOR=Khawar Muhammad Babar , Gao Hui , Li Wei 

TITLE=Mechanism of Acrosome Biogenesis in Mammals

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 7 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2019.00195

DOI=10.3389/fcell.2019.00195

ISSN=2296-634X

ABSTRACT=During sexual reproduction, two haploid gametes fuse to form the zygote, and the acrosome is essential to this fusion process (fertilization) in animals. The acrosome is a special kind of organelle with a cap-like structure that covers the anterior portion of the head of a the spermatozoon. The acrosome is derived from the Golgi apparatus and contains digestive enzymes. With the progress of our understanding underlying of acrosome biogenesis, a number of models have been proposed to address the origin of the acrosome.  The acrosome has been regarded as a lysosome-related organelle, and it has been proposed to have originated from the lysosome or the autolysosome. Our review will provide a brief historical overview and highlight recent findings on acrosome biogenesis in mammals.