AUTHOR=Yang Huihui , Huang Kaiyao 

TITLE=Dissecting the Vesicular Trafficking Function of IFT Subunits

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 7 - 2019

YEAR=2020

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2019.00352

DOI=10.3389/fcell.2019.00352

ISSN=2296-634X

ABSTRACT=Intraflagellar transport (IFT) is initially identified as a transport machine with multiple protein subunits, and is essential for the assembly, disassembly, and maintenance of cilium/flagellum, which serves as the nexus of extracellular-to-intracellular signal integration. To date, in addition to well-established and indispensable roles in ciliated cells, most IFT subunits have also shown more general roles of vesicular trafficking in non-ciliated cells. Thus, the purpose of this review is to summary the recent progress on vesicular trafficking functions of IFT protein and highlight the problems in future research.