AUTHOR=Ying Zhenguang , Yang Jing , Li Wei , Wang Xia , Zhu Zeyao , Jiang Weipeng , Li Chunman , Sha Ou 

TITLE=Astrin: A Key Player in Mitosis and Cancer

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 8 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.00866

DOI=10.3389/fcell.2020.00866

ISSN=2296-634X

ABSTRACT=Astrin, which is a spindle-associated protein, was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the kinetochore-microtubule, and ensuring accurate segregation of the chromosomes, and the timely onset of anaphase. In addition, Astrin was quite recently found to be abnormally expressed in a variety of cancers. Astrin promotes the occurrence and metastasis of cancer by participating in various molecular pathways, and is considered an important prognostic and survival predictor.