AUTHOR=Brockmann Kathrin TITLE=GBA-Associated Synucleinopathies: Prime Candidates for Alpha-Synuclein Targeting Compounds JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=Volume 8 - 2020 YEAR=2020 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.562522 DOI=10.3389/fcell.2020.562522 ISSN=2296-634X ABSTRACT=As we are now entering the era where disease-modifying treatment options such as alpha-synuclein targeting compounds are tested in clinical trials, patient stratification according to alpha-synuclein-specific enrichment strategies are a much-needed prerequisite to introduce patients to specific therapies. Such a scenario will be exemplified for GBA, one major genetic risk factor that is specifically associated with the alpha-synucleinopathies Parkinson’s Disease and Dementia with Lewy Bodies.