AUTHOR=Zhang Lu-Qiang , Fan Guo-Liang , Liu Jun-Jie , Liu Li , Li Qian-Zhong , Lin Hao 

TITLE=Identification of Key Histone Modifications and Their Regulatory Regions on Gene Expression Level Changes in Chronic Myelogenous Leukemia

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 8 - 2020

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.621578

DOI=10.3389/fcell.2020.621578

ISSN=2296-634X

ABSTRACT=Chronic myelogenous leukemia (CML) is a type of cancer with a series of characteristics that make it particularly suitable for observations on leukemogenesis. Researches have exhibited that the occurrence and progression of CML are associated with the dynamic alternations of histone modification (HM) patterns. In this study, we analyze the distribution patterns of 11 HM signals and calculate the signal changes of these HMs in CML cell lines as compared with that in normal cell lines. Meanwhile, the impacts of HM signal changes on expression level changes of CML-related genes are investigated. Based on the alternations of HM signals between CML and normal cell lines, the up- and down-regulation genes are predicted by the Random Forest algorithm to identify the key HMs and their regulatory regions. Researches show that H3K79me2, H3K36me3 and H3K27ac are key HMs to expression level changes of CML-related genes in leukemogenesis. Especially, H3K79me2 and H3K36me3 perform their important functions in all studied 100 bins. Our researches reveal that H3K79me2 and H3K36me3 may be the core HMs for the clinical treatment of CML.