AUTHOR=Xu Jing , Huang Yan , Zhao Jimeng , Wu Luyi , Qi Qin , Liu Yanan , Li Guona , Li Jing , Liu Huirong , Wu Huangan 

TITLE=Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.599065

DOI=10.3389/fcell.2021.599065

ISSN=2296-634X

ABSTRACT=Cofilin is an actin-binding protein that regulates filament dynamics and depolymerysion. The over-expression of cofilin is observed in various cancers, cofilin promotes cancer metastasis by regulating cytoskeletal reorganization, lamellipodium formation and epithelial-to-mesenchymal transition. Clinical treatment of cancer regarding cofilin has been explored in aspects of tumour cells apoptosis and cofilin related miRNAs. This review addresses the structure and phosphorylation of cofilin and describes recent findings regarding the function of cofilin in regulating cancer metastasis and apoptosis in tumour cells.