AUTHOR=Tang Ming , Bolderson Emma , O’Byrne Kenneth J. , Richard Derek J. 

TITLE=Tumor Hypoxia Drives Genomic Instability

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.626229

DOI=10.3389/fcell.2021.626229

ISSN=2296-634X

ABSTRACT=Cancer is a leading cause of death worldwide. As a hallmark of cancer, hypoxia is associated with poor prognosis due to enhanced tumour malignancy and therapeutic resistance. The enhanced tumour aggressiveness stems at least partially from hypoxia-induced genomic instability. Therefore, a clear understanding of how tumour hypoxia induces genomic instability is crucial for the improvement of cancer therapeutics. This minireview summarises recent developments highlighting the association of tumour hypoxia with genomic instability and the mechanisms by which tumour hypoxia drives genomic instability, followed by how hypoxic tumours can be specifically targeted to maximise efficacy.