AUTHOR=Zhao Shizhen , Li Xiaotian , Li Xinping , Wei Xiaoyun , Wang Honggang 

TITLE=Hydrogen Sulfide Plays an Important Role in Diabetic Cardiomyopathy

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.627336

DOI=10.3389/fcell.2021.627336

ISSN=2296-634X

ABSTRACT=Cardiovascular diseases is an important complication of diabetes mellitus and the main cause of diabetes death. Diabetic cardiovascular diseases, including diabetic cardiomyopathy and diabetic vascular diseases, are related to many factors, such as hyperglycemia, lipid accumulation, oxidative stress, myocarditis and apoptosis. Hydrogen sulfide (H2S) is a newly discovered signal molecule, which plays an important role in many physiological and pathological processes. Recent studies have shown that H2S is involved in improving diabetic cardiovascular disease, but its mechanism has not been fully elucidated. This review summarizes the researches on the roles and its mechanisms of H2S in diabetic cardiovascular diseases in recent years to provide the basis for the in depth research in the future.