AUTHOR=Du Hang , Xu Weili , Zhang Zhizhou , Han Xiaojun TITLE=Bacterial Behavior in Confined Spaces JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=Volume 9 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.629820 DOI=10.3389/fcell.2021.629820 ISSN=2296-634X ABSTRACT=In confined spaces, bacteria exhibit unexpected cellular behaviors, which are related to the biogeochemical cycle and human health. The types of confined spaces include lipid vesicles, polymer vesicles, emulsion droplets, microfluidic chips, and different lab-made chambers. In this mini-review, the behaviors of living bacteria in these confined spaces, including a) growth and proliferation, b) cell communication, and c) motion, are summarized. The future trends and challenges are also discussed in the paper.