AUTHOR=Cao Yu , Yang Zhao , Chen Ying , Jiang Shuai , Wu Zhen , Ding Baoping , Yang Yang , Jin Zhenxiao , Tang Haifeng 

TITLE=An Overview of the Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.630401

DOI=10.3389/fcell.2021.630401

ISSN=2296-634X

ABSTRACT=Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized by its complexity, high mortality, and the lack of effective diagnosis and treatment methods. Many studies focusing on the diagnosis and treatment of diabetes mellitus (DM) and DN have reported that the pathogenesis and pathophysiology of DN are very complex, involving many molecules and abnormal cellular activities. We first review the effect of posttranscriptional modifications on vital molecules involved in DN including NF-κB, Nrf2 and TGF-β. Then, we describe the relationship between these molecules and related abnormal cellular activities in DN. Finally, we discuss some potential directions for DN treatment and diagnosis. The information reviewed here may be significant in the design of further studies to identify valuable therapeutic targets for DN.