AUTHOR=Yan Yan-yan , Guo Qiao-ru , Wang Feng-hua , Adhikari Rameshwar , Zhu Zhuang-yan , Zhang Hai-yan , Zhou Wen-min , Yu Hua , Li Jing-quan , Zhang Jian-ye 

TITLE=Cell-Free DNA: Hope and Potential Application in Cancer

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.639233

DOI=10.3389/fcell.2021.639233

ISSN=2296-634X

ABSTRACT=Cell-free DNA (cfDNA) could serve as a novel and easily accessible biomarker in many cancers. A broad range of cfDNA applications are currently being investigated by multiple international research groups and companies, touching different stages of cancer management. In this review, we will discuss the potential clinical relevance of cfDNA in oncology: cancer diagnosis and early screening; cancer therapeutic effect evaluation and monitoring disease progression; and prognosis determination.