AUTHOR=Gai Wenbin , Peng Zhiqiang , Liu Cui Hua , Zhang Lingqiang , Jiang Hong 

TITLE=Advances in Cancer Treatment by Targeting the Neddylation Pathway

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.653882

DOI=10.3389/fcell.2021.653882

ISSN=2296-634X

ABSTRACT=Developmental down-regulation protein 8 (NEDD8) expressed by neural progenitor is a ubiquitin-like protein that conjugates to and regulates the biological function of its substrates. The main target of NEDD8 is cullin-RING E3 ligases. Upregulation of the neddylation pathway is closely associated with the advance of various tumours, and MLN4924 which inhibits NEDD8 activating enzyme (NAE), has great potential as a new antitumour compound for combination therapy. Here, we summarize the latest progress in anticancer strategies targeting the neddylation pathway and their combined applications, providing a theoretical reference for the development of antitumour drugs and combination therapies.