AUTHOR=Zhao Shizhen , Li Xiaotian , Wang jie , Wang Honggang 

TITLE=The Role of the Effects of Autophagy on NLRP3 Inflammasome in Inflammatory Nervous System Diseases

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.657478

DOI=10.3389/fcell.2021.657478

ISSN=2296-634X

ABSTRACT=Autophagy is a self-sustaining process of internal environment stability in eukaryotic cells. In this process, pathogens, abnormal proteins and organelles are wrapped in double-layer membranes to form autophagosomes, which are then transferred to lysosomes for degradation. Autophagy participates in a variety of physiological and pathological processes. Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, containing NLRP3, apoptosis associated speck like protein (ASC) and pro-caspase-1, can activate caspase-1 to lead to pyroptosis and induce the maturation and secretion of interleukin-1β (IL-1β) and IL-18. NLRP3 inflammasome is related with many diseases. In recent years, it has been reported that autophagy plays an important role by influencing NLRP3 inflammasome in many diseases including inflammatory nervous system diseases. In this review, we summarized the recent studies about the effects of autophagy on NLRP3 inflammasome in inflammatory nervous system diseases to provide ideas for the relevant basic research in the future.