AUTHOR=Liu Jiarui , Han Yang , Hu Shunfeng , Cai Yiqing , Yang Juan , Ren Shuai , Zhao Yi , Lu Tiange , Zhou Xiangxiang , Wang Xin 

TITLE=Circulating Exosomal MiR-107 Restrains Tumorigenesis in Diffuse Large B-Cell Lymphoma by Targeting 14-3-3η

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.667800

DOI=10.3389/fcell.2021.667800

ISSN=2296-634X

ABSTRACT=Exosomes, nanometer-sized membranous vesicles in body fluids, have emerged as promising non-invasive biomarkers for cancer diagnosis. However, the function of exosomes in diffuse large B-cell lymphoma (DLBCL) remains elusive. This study aimed to investigate the role of exosomal miR-107 in lymphomagenesis and explore its clinical significance. In this study, decreased exosomal miR-107, miR-375-3p and upregulated exosomal miR-485-3p were detected in the plasma of DLBCL patients and showed potential diagnostic value. Downregulated miR-107 expression was associated with advanced Ann Abor stage, high IPI score, LDH and β2-MG level in DLBCL patients. Overexpression of miR-107 by miR-107 Agomir significantly abrogated cell proliferation, induced apoptosis and inhibited cell invasion in vitro and repressed tumor growth in vivo. Moreover, downregulation of miR-107 went into the opposite effect. The target genes of miR-107 were mainly enriched in the PI3K-Akt, Hippo and AMPK signaling pathways. Notably, 14-3-3η (YWHAH), which was upregulated in DLBCL, was suppressed by miR-107, suggesting that miR-107 may restrain tumorigenesis by targeting 14-3-3η. In summary, this study unveils the function of miR-107 in lymphomagenesis, highlights its potential as diagnostic and prognostic indicator, and as new therapeutic target in DLBCL management.