AUTHOR=Li Dan , Yang Shengjie , Xing Yanwei , Pan Limin , Zhao Ran , Zhao Yixi , Liu Longtao , Wu Min 

TITLE=Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.673839

DOI=10.3389/fcell.2021.673839

ISSN=2296-634X

ABSTRACT=Cardiovascular disease (CVD) is the leading cause of death in the world, and atherosclerosis is the main underlying pathology of CVD. Lipid deposition, oxidative stress, inflammation and endothelial injury are the main causes of atherosclerotic plaques. Obesity, diabetes, hypertension and smoking are risk factors that aggravate the progression of cardiovascular diseases. In recent years, more and more evidences show that abnormal mitochondrial function may be an important cause of atherosclerosis. Mitochondrial fusion and division is an important basis for maintaining its homeostasis and functional realization. Mitochondrial dynamics may be a new target for atherosclerosis therapy, however, the specific mechanism remains unclear. This article provides a detailed overview of the current research in this area of study.