AUTHOR=Liu Xuda , Wang Haiying , Liu Bingchen , Qi Zhipeng , Li Jiashuo , Xu Bin , Liu Wei , Xu Zhaofa , Deng Yu 

TITLE=The Latest Research Progress of m6A Modification and Its Writers, Erasers, Readers in Infertility: A Review

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.681238

DOI=10.3389/fcell.2021.681238

ISSN=2296-634X

ABSTRACT=We summarized the scientific literature published from 2012 to 2020 on the effects of RNA methylation m6A modification on the fertility of both sexes. We focused on the effects of m6A modification (e.g., methyltransferase 'Writers', demethylase 'Erasers', binding protein 'Readers') on gametogenesis (e.g., spermatogenesis, oogenesis). Literature review shows that RNA methylation m6A modification may be related to infertility. Potential explanations for this association can be generated from experimental studies. Specifically, m6A modification catalyzes the formation of m6A of mRNA under the influence of methyltransferase, completes the demethylation of mRNA by demethylase, and then is specifically recognized by m6A binding protein, which plays an important role in the process of gametogenesis. Normal gametogenesis is the basic guarantee for fertility, and the dysfunction of m6A modification is likely to cause obstacles to gametogenesis, leading to infertility. This has promoted in-depth research on the RNA methylation mechanism of gametogenesis, in order to better understand the close relationship between m6A modification and gametogenesis and fertility, and provide potential preventable targets for the treatment of infertility. And provide clues for the research and development of related drugs, so such research has important positive significance.