AUTHOR=Liu Xuda , Wang Haiying , Liu Bingchen , Qi Zhipeng , Li Jiashuo , Xu Bin , Liu Wei , Xu Zhaofa , Deng Yu 

TITLE=The Latest Research Progress of m6A Modification and Its Writers, Erasers, Readers in Infertility: A Review

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.681238

DOI=10.3389/fcell.2021.681238

ISSN=2296-634X

ABSTRACT=<p>Eukaryotic messenger mRNAs contain many RNA methyl chemical modifications, in which N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) plays a very important role. The modification process of RNA methylation is a dynamic reversible regulatory process that is mainly catalyzed by “Writer” m<sup>6</sup>A methyltransferase, removed by “Eraser” m<sup>6</sup>A demethylase, and recognized by the m<sup>6</sup>A binding protein, thereby, linking m<sup>6</sup>A modification with other mRNA pathways. At various stages of the life cycle, m<sup>6</sup>A modification plays an extremely important role in regulating mRNA splicing, processing, translation, as well as degradation, and is associated with gametogenesis and fertility for both sexes. Normal gametogenesis is a basic guarantee of fertility. Infertility leads to trauma, affects harmony in the family and seriously affects the quality of life. We review the roles and mechanisms of RNA m<sup>6</sup>A methylation modification in infertility and provide a potential target for infertility treatment, which can be used for drug development.</p>