AUTHOR=Zhan Chuanchuan , Xu Chao , Chen Jiajun , Shen Chong , Li Jinkun , Wang Zichu , Ying Xiangrong , Luo Zhengang , Ren Yu , Wu Gangfeng , Zhang Haojie , Qian Manfei 

TITLE=Development and Validation of an IL6/JAK/STAT3-Related Gene Signature to Predict Overall Survival in Clear Cell Renal Cell Carcinoma

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.686907

DOI=10.3389/fcell.2021.686907

ISSN=2296-634X

ABSTRACT=Background:
In predictive prognosis accuracy of clear cell renal cell carcinoma (ccRCC), traditional clinicopathological features (TNM, pathology grade) are often insufficient. The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis which is revealed to act as a promising prognosis indicator. The relation between IL-6/JAK/STAT3 pathway and ccRCC is still unknown.
Methods: We evaluated the levels of various hallmarks of cancer and filtered out the promising risk hallmarks in ccRCC. Subsequently, via weighted correlation network analysis and Cox regression analysis, a prognosis model based on promising risk hallmarks-related genes was established. Besides, we constructed a nomogram based on the previous model with traditional clinicopathological features to improve the predictive power and accuracy.
Results: The IL-6/JAK/STAT3 pathway was identified as the promising risk hallmarks in ccRCC and the pathway-related prognosis model was constructed with five genes. Also, the nomogram we constructed showed the strongest and most stable survival predictive ability.
Conclusions: our study would provide new sights for guiding individualized treatment of ccRCC patients.