AUTHOR=Chen Yunqing , Fan Hongyan , Wang Shijun , Tang Guanmin , Zhai Changlin , Shen Liang 

TITLE=Ferroptosis: A Novel Therapeutic Target for Ischemia-Reperfusion Injury

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.688605

DOI=10.3389/fcell.2021.688605

ISSN=2296-634X

ABSTRACT=Ischemia-reperfusion (I/R) injury is a major cause of cell death and organ damage in numerous pathological states, such as myocardial infarction, stoke and acute kidney injury. Nowadays, treatment methods for I/R injury remain limited. Ferroptosis, a new type of regulated cell death, which is characterized by iron overload and accumulation of lipid peroxidation, has been investigated in various diseases. A growing number of evidence has shown that there is a close association between ferroptosis and I/R injury. Ferroptosis is identified as a new therapeutic target for the management of I/R injury. This review summarizes the current status of ferroptosis and discusses the relationship between ferroptosis and I/R injury as well as potential treatment strategy targeting ferroptosis.