AUTHOR=Li Hong , Jiang Xueqin , Shen Xin , Sun Yueshan , Jiang Nan , Zeng Jing , Lin Jing , Yue Liang , Lai Jia , Li Yan , Wu Anguo , Wang Long , Qin Dalian , Huang Feihong , Mei Qibing , Yang Jing , Wu Jianming TITLE=TMEA, a Polyphenol in Sanguisorba officinalis, Promotes Thrombocytopoiesis by Upregulating PI3K/Akt Signaling JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=Volume 9 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.708331 DOI=10.3389/fcell.2021.708331 ISSN=2296-634X ABSTRACT=
Thrombocytopenia is closely linked with hemorrhagic diseases, for which induction of thrombopoiesis shows promise as an effective treatment. Polyphenols widely exist in plants and manifest antioxidation and antitumour activities. In this study, we investigated the thrombopoietic effect and mechanism of 3,3′,4′-trimethylellagic acid (TMEA, a polyphenol in