AUTHOR=Luo Meng-Yi , Su Jian-Hui , Gong Shao-Xin , Liang Na , Huang Wen-Qian , Chen Wei , Wang Ai-Ping , Tian Ying 

TITLE=Ferroptosis: New Dawn for Overcoming the Cardio-Cerebrovascular Diseases

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.733908

DOI=10.3389/fcell.2021.733908

ISSN=2296-634X

ABSTRACT=The dynamic balance of cardiomyocytes and neurons is essential to maintain normal physiological functions of heart and brain. If redundant cells die in tissues, serious cardio-cerebrovascular diseases would occur such as hypertension, myocardial infarction and ischemic stroke. The regulation of cell death plays a role in promoting or alleviating cardio-cerebrovascular diseases. Ferroptosis is an iron-dependent new type of cell death that has been proved to occur in a variety of diseases. In this review, we focus on the critical role of ferroptosis and its regulatory mechanisms involved in cardio-cerebrovascular diseases, and discusses the important function of ferroptosis-related inhibitors, which will provide the potential targets and strategies for the prevention and treatment of cardio-cerebrovascular diseases.