AUTHOR=Shao Bo , Dang Qin , Chen Zhuang , Chen Chen , Zhou Quanbo , Qiao Bingbing , Liu Jinbo , Hu Shengyun , Wang Guixian , Yuan Weitang , Sun Zhenqiang 

TITLE=Effects of Tumor-Derived Exosome Programmed Death Ligand 1 on Tumor Immunity and Clinical Applications

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.760211

DOI=10.3389/fcell.2021.760211

ISSN=2296-634X

ABSTRACT=Programmed death ligand 1 (PD-L1) is a typical immune surface protein that binds to programmed cell death 1 (PD-1) on T cells through its extracellular domain. Subsequently, T cell activity is inhibited and tumor immune tolerance is enhanced. Studies have shown that PD-L1 is not only expressed on the cell surface but also released from tumor cells. In particular, exosomal PD-L1 plays an unfavorable role in tumor immunosuppression. This review aims to summarize the available evidence regarding the biological characteristics of exosomal PD-L1 in tumor immunity, with a particular focus on the mechanisms in different cancers and clinical prospects.