AUTHOR=Zhang Yiyu , Huang Guoqing , Yuan Zhaohu , Zhang Yonggang , Chang Rong 

TITLE=Circular RNA Expression for Dilated Cardiomyopathy in Hearts and Pluripotent Stem Cell–Derived Cardiomyocytes

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.760515

DOI=10.3389/fcell.2021.760515

ISSN=2296-634X

ABSTRACT=Dilated Cardiomyopathy (DCM) is a type of heart disease delimited by enlargement and dilation of one or both of the ventricles along with damaged contractility, which is accompanied by left ventricular ejection fraction (LVEF) less than 40%. DCM is progressive and always leads to heart failure. Circular RNAs (circRNAs) are unique species of noncoding RNA featuring high cell-type specificity and long-lasting conservation, which normally are involved in the regulation of heart failure and DCM recently. So far, a landscape of variety single gene or poly gene mutations which can cause complex human cardiac disorders, have been investigated by human induced pluripotent stem cell (hiPSC) technology. Furthermore, DCM has been modeled as well, providing new perspectives on disease study at cellular level. In addition, current genome editing methods can not only repair defects of some genes, but also rescue the disease phenotype in patient-derived iPSCs, and even introduce pathological-related mutations into wild-type strains. In  this review, we gather up the aspects of circRNAs expression and mechanism in DCM diseases scenery, facilitating understanding in DCM development and pathophysiology in molecular level. Also, we offer an update on the most relevant scientific progress in iPSC's modeling of gene mutations induced DCM.