AUTHOR=Li Yinchuan , Mi Panpan , Chen Xue , Wu Jiabao , Liu Xiaohua , Tang Yunge , Cheng Jinmei , Huang Yingying , Qin Weibing , Cheng C. Yan , Sun Fei 

TITLE=Tex13a Optimizes Sperm Motility via Its Potential Roles in mRNA Turnover

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.761627

DOI=10.3389/fcell.2021.761627

ISSN=2296-634X

ABSTRACT=During the late stages of spermiogenesis, mRNAs have been reported to undergo massive selective degradation. However, the mechanisms regulating this biological process are unknown. In this report, we have identified a spermatid-specific gene, Tex13a, which was found to be involved in the targeted degradation of mRNAs encoding certain structural components of sperm via CCR4-NOT complex. Deletion of Tex13a led to a delayed decay of these mRNAs, lowered the levels of house-keeping genes and ultimately affected several key parameters associated with the control of sperm motility.