AUTHOR=Deng Jianxin , Liao Yunxiu , Liu Jianpin , Liu Wenjuan , Yan Dewen 

TITLE=Research Progress on Epigenetics of Diabetic Cardiomyopathy in Type 2 Diabetes

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.777258

DOI=10.3389/fcell.2021.777258

ISSN=2296-634X

ABSTRACT=Diabetic cardiomyopathy (DCM) is characterized in its early stages by diastolic relaxation abnormalities and later by clinical heart failure in the absence of dyslipidemia, hypertension, and coronary artery disease. DCM contributes to high mortality and morbidity in diabetic populations and diabetes is a polygenic, heritable and a complex disease, and the environmental factor combined action. Recent studies have demonstrated that epigenetics directly or indirectly contributes to the pathogenesis of DCM. Although the role of epigenetic mechanisms (such as DNA methylation, histone modifications, and non-coding RNAs) have been recognized in the pathogenesis of DCM. However, its role in DCM remains largely unexplored. Better understanding of the research progress of epigenetics will provide a new measure to prevent and treat DCM.