AUTHOR=Liu Wenwen , Zhang Lingfeng , Gao Anning , Khawar Muhammad Babar , Gao Fengyi , Li Wei 

TITLE=Food-Derived High Arginine Peptides Promote Spermatogenesis Recovery in Busulfan Treated Mice

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.791471

DOI=10.3389/fcell.2021.791471

ISSN=2296-634X

ABSTRACT=Food-derived peptides with high arginine content have important applications in medicine and food industries, but their potential application in the treatment of oligoasthenospermia remains largely elusive. Here, we report that high-arginine peptides, such as Oyster peptides (Opp) and Perilla purple peptides (Ppp), were able to promote spermatogenesis recovery in busulfan-treated mice. We found that both Opp and Ppp could increase sperm concentration and motility after busulfan-induced testicular damage in mice. Further research revealed that Opp and Ppp might promote spermatogonia proliferation, which improved blood-testis barrier (BTB) recovery between Sertoli cells. Taken together, these high-arginine peptides could be used as a medication or therapeutic component of a diet prescription to improve the fertility of some oligoasthenospermia patients.