AUTHOR=Hun Marady , Wen Huai , Han Phanna , Vun Tharith , Zhao Mingyi , He Qingnan 

TITLE=Bibliometric analysis of scientific papers on extracellular vesicles in kidney disease published between 1999 and 2022

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.1070516

DOI=10.3389/fcell.2022.1070516

ISSN=2296-634X

ABSTRACT=Recently, there has been an increasing interest in extracellular vesicles (EVs) for use as potential therapeutic agents or natural drug delivery systems in kidney-related diseases. However, a detailed and targeted report on the recent condition of EVs research in kidney-related diseases is lacking. Therefore, this prospective study was designed to investigate the use of bibliometric analysis in a comprehensive overview of the current state of research and frontier trends in the field of EVs research in kidney-related diseases using visualization tools. The WoSCC was searched to identify publications related to EV research in kidney-related diseases since 1999. The Citespace, VOS Viewer software, the R Bibliometrix Package, and one online platform were used to analyze related research trends and stratify publication data and collaborations. From 1 January 1999 to 26 June 2022, a total of EVs 1122 articles and reviews were included. The number of articles regarding EVs in kidney-related diseases speedily rose yearly. It was reported that 6,486 authors from 1,432 institutions in 63 countries or regions have investigated the role of EVs in kidney-related diseases. The dozens of publications were from China and the United States, of which China conserved the dominant position in this field; meanwhile, Southeast University was the most active institution in all fields. Liu Bi-cheng, published the most papers on EVs, while Clotilde Théry had the most co-citations. The International Journal of Molecular Sciences published the most papers, while Kidney International was the most co-cited journal for EVs. We found that keywords from exosome related including exosome, extracellular vesicle, microvesicle, liquid biopsy; disease-related and pathological process-related include biomarker, microRNA, apoptosis, mechanism, systemic-lupus-erythematosus, acute kidney injury, chronic kidney disease. And AKI, CKD, SLE, exosome, liquid biopsy, and extracellular vesicle were the hotspot in EVs and kidney-related diseases research. The field of this field is in a fast upgrowth stage and its domain is likely to expand in the next decade. This research disseminates an all-around analysis of EVs in kidney-related diseases research, which may supply beneficial consults for investigators in this domain, and set new diagnostic, therapeutic, and prognostic ideas or methods in kidney-related diseases.