AUTHOR=Yuan Xin , Dong Zihui , Shen Shen 

TITLE=LncRNA GACAT3: A Promising Biomarker and Therapeutic Target in Human Cancers

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.785030

DOI=10.3389/fcell.2022.785030

ISSN=2296-634X

ABSTRACT=<p>Long non-coding RNAs (lncRNAs) are a class of functional RNA molecules that do not encode proteins and are composed of more than 200 nucleotides. LncRNAs play important roles in epigenetic and gene expression regulation. The oncogenic lncRNA <italic>GACAT3</italic> was recently discovered to be dysregulated in many tumors. Aberrant expression of <italic>GACAT3</italic> contributes to clinical characteristics and regulates multiple oncogenic processes. The association of <italic>GACAT3</italic> with a variety of tumors makes it a promising biomarker for diagnosis, prognosis, and targeted therapy. In this review, we integrate the current understanding of the pathological features, biological functions, and molecular mechanisms of <italic>GACAT3</italic> in cancer. Additionally, we provide insight into the utility of <italic>GACAT3</italic> as an effective diagnostic and prognostic marker for specific tumors, which offers novel opportunities for targeted therapeutic intervention.</p>