AUTHOR=Guo Junjie , Xu Fengqiang , Ji Hongwei , Jing Yajun , Shen Li , Weng Xinyu , Hu Longgang 

TITLE=Isolevuglandins Scavenger Ameliorates Myocardial Ischemic Injury by Suppressing Oxidative Stress, Apoptosis, and Inflammation

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.836035

DOI=10.3389/fcell.2022.836035

ISSN=2296-634X

ABSTRACT=Increased levels of reactive isolevuglandins (IsoLGs) are associated with cardiovascular disease. The role of IsoLGs in myocardial infarction (MI) is unknown. Here we studied the role of IsoLG scavenger 2-hydroxybenzylamine (2-HOBA) in post-Infarction cardiac repair. We observed that infarct cardiac tissue expressed a high level of IsoLG in mice. Following MI injury, 2-HOBA treated mice exhibited smaller myocardial infarction along with improved heart function compared with control littermates. Moreover, 2-HOBA effectively attenuated MI induced cardiac remodeling, oxidative stress, apoptosis, and inflammation. Whereas, 4-hydroxybenzylamine (4-HOBA), a less reactive isomer of 2-HOBA, barely antagonized the MI-induced injury. These findings suggest that methods to reduce IsoLGs may be useful for MI therapy.