AUTHOR=Carrà Giovanna , Avalle Lidia , Seclì Laura , Brancaccio Mara , Morotti Alessandro 

TITLE=Shedding Light on NF-κB Functions in Cellular Organelles

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.841646

DOI=10.3389/fcell.2022.841646

ISSN=2296-634X

ABSTRACT=NF-κB is diffusely recognized as a transcriptional factor able to modulate the expression of vari-ous genes involved in a broad spectrum of cellular functions, including proliferation, survival and migration. NF-κB is, however, also acting outside the nucleus and beyond its ability to binds to DNA. NF-κB is indeed found to localize inside different cellular organelles, such as mi-tochondria, endoplasmic reticulum, Golgi and nucleoli, where it acts through different partners in mediating various biological functions. Here, we discuss the relationship linking NF-κB to the cellular organelles, and how this crosstalk between cellular organelles and NF-κB signalling may be evaluated for anticancer therapies.