AUTHOR=Gridnev Artem , Misra Jyoti R. 

TITLE=Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.842593

DOI=10.3389/fcell.2022.842593

ISSN=2296-634X

ABSTRACT=Fat and Dachsous are evolutionarily conserved cell adhesion molecules that play a critical role in development of multiple organ systems. Much of our understanding of this signaling pathway comes from studies from  Drosophila, where they initiate a signaling pathway that regulate growth by influencing Hippo signaling and morphogenesis by regulating Planar Cell Polarity (PCP). In this review, we discuss recent advances in our understanding of the mechanisms by which this signaling pathway regulates these developmental processes. Further, we discuss the progress in understanding how they function in mammals.