AUTHOR=Wang Junqi , Liu Han 

TITLE=The Roles of Junctional Adhesion Molecules (JAMs) in Cell Migration

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.843671

DOI=10.3389/fcell.2022.843671

ISSN=2296-634X

ABSTRACT=The review briefly summarized the role of the family of adhesion molecules JAMs (Junctional adhesion molecules) in various cell migration, covering germ cells, epithelial cells, endothelial cells, several leukocytes and different cancer cells. These functions affect multiple diseases, including reproductive diseases, inflammation-related diseases, cardiovascular diseases and cancers. JAMs bind to both similar and dissimilar proteins and take both similar and dissimilar effects in different cells. Concluding relevant results provides a reference to further researches.