AUTHOR=Komada Munekazu , Nishimura Yuhei 

TITLE=Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.852752

DOI=10.3389/fcell.2022.852752

ISSN=2296-634X

ABSTRACT=Neuroinflammation is a cause of neurodevelopmental disorders such as autism spectrum disorders and fetal alcohol syndrome. Converging lines of evidence from basic and clinical sciences suggest that dysregulation of the epigenetic landscape, including histone modification, DNA methylation, and microRNA expression, is associated with neuroinflammation. Both genetic and environmental factors can affect the interaction between epigenetics and neuroinflammation, which may cause neurodevelopmental disorders. In this minireview, we focus on epigenetic dysregulation in microglia, which regulate neuroinflammation, and compare studies using mammals and zebrafish.