AUTHOR=Xu Ying , Pei Weiwei , Hu Wentao 

TITLE=A Current Overview of the Biological Effects of Combined Space Environmental Factors in Mammals

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.861006

DOI=10.3389/fcell.2022.861006

ISSN=2296-634X

ABSTRACT=Space environmental factors include microgravity, space radiation, hypomagnetic field, circadian rhythm changes, and so on, which pose lots of adverse effects on the safety and health of astronauts during deep space exploration missions. However, most of the current ground-based studies focused on single-factor biological effects. In order to better understand the biological effects of space environment and the underlying mechanisms and promote the manned space exploration, it is necessary to deeply study the compound biological effects of space environmental factors. This paper summarizes the latest research progress on the compound biological effects of various space environmental factors in order to provide new directions for further exploring the health effects of space environmental factors and the underlying mechanisms, in hope of providing reference for the diagnosis and treatment of diseases induced by space environment.