AUTHOR=Chen Lei , Qin Yuan , Liu Bilin , Gao Meng , Li Anqi , Li Xue , Gong Guohua 

TITLE=PGC-1α-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.871357

DOI=10.3389/fcell.2022.871357

ISSN=2296-634X

ABSTRACT=Mitochondria with structural and functional integrity are essential for maintaining mitochondrial dysfunction and cardiac homeostasis. Peroxisome proliferator-activated receptor γ coactivator 1 alpha (PGC-1α), acted as a transcriptional cofactor, is abundant in the heart, which modulates mitochondrial biogenesis and mitochondrial dynamics and mitophagy to sustain a steady-state of mitochondria. Cumulative evidence suggests that dysregulation of PGC-1α is closely related to the onset and progression of heart failure. PGC-1α deficient-mice can lead to worse cardiac function under pressure overload. Here, this review mainly focuses on what is known about the structure of PGC-1α and its regulation in mitochondrial functions, as well as its crucial role in heart failure.