AUTHOR=Vogenstahl Johanna , Parrilla Marta , Acker-Palmer Amparo , Segarra Marta 

TITLE=Vascular Regulation of Developmental Neurogenesis

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.890852

DOI=10.3389/fcell.2022.890852

ISSN=2296-634X

ABSTRACT=Evolutionary studies indicate that the nervous system evolved before the vascular system, but the increasing complexity of organisms prompted the vascular system to emerge to meet the growing demand for oxygen and nutrient supply. In recent years, it has become apparent that the symbiotic communication between the nervous and the vascular system goes beyond the exclusive covering of the demands of nutrients and oxygen carried by the blood vessels. Indeed, this active interplay between both systems plays a key role during the development of the central nervous system (CNS). Several neural-derived signals have been described to initiate and regulate the vascularization of the CNS, however less is known about the vascular signals that orchestrate the development of the CNS cytoarchitecture. Here, we focus on reviewing the effect of blood vessels in the process of neurogenesis during CNS development in vertebrates. In mammals, we describe the spatiotemporal features of vascular-driven neurogenesis in two brain regions that exhibit different neurogenic complexity in their germinal zone, the hindbrain and the forebrain.