AUTHOR=Feng Jiawei , Wang Jialin , Wang Yuqing , Huang Xiaoting , Shao Tengteng , Deng Xiaofei , Cao Yemin , Zhou Mingmei , Zhao Cheng 

TITLE=Oxidative Stress and Lipid Peroxidation: Prospective Associations Between Ferroptosis and Delayed Wound Healing in Diabetic Ulcers

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.898657

DOI=10.3389/fcell.2022.898657

ISSN=2296-634X

ABSTRACT=Diabetic ulcers are one of the major complications of diabetes, and patients usually suffer from amputation and death due to delayed ulcer wound healing. Persistent inflammation and oxidative stress at the wound site are the main manifestations of delayed wound healing in diabetic ulcers. In addition, chronic hyperglycemia in patients can lead to circulatory accumulation of lipid peroxidation products and impaired iron metabolism pathways leading to the presence of multiple free irons in plasma. Ferroptosis, a newly discovered form of cell death, is characterized by intracellular iron overload and accumulation of iron-dependent lipid peroxides. These indicate that ferroptosis is one of the potential mechanisms of delayed wound healing in diabetic ulcers and will hopefully be a novel therapeutic target for delayed wound healing in diabetic patients. In this review, we explored the pathogenesis of diabetic ulcer wound healing, the pathological basis and influencing factors of ferroptosis and delayed wound healing in diabetic ulcers, among which oxidative stress and lipid peroxidation are their common key mechanisms. Ferroptosis inhibitors provide new ideas for exploring clinical treatment of diabetic ulcers and are promising therapeutic agents for the treatment of diabetic ulcers.