AUTHOR=Chen Ganyi , Jiang Hongwei , Yao Yiwei , Tao Zhonghao , Chen Wen , Huang Fuhua , Chen Xin 

TITLE=Macrophage, a potential targeted therapeutic immune cell for cardiomyopathy

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.908790

DOI=10.3389/fcell.2022.908790

ISSN=2296-634X

ABSTRACT=Cardiomyopathy is an important cause of heart failure, causing systolic and diastolic dysfunction and promoting adverse cardiac remodeling. Macrophages, as important immune cells of the heart, play a decisive role in inflammation and fibrosis. What’s more, there are functional and phenotypic differences between exogenous macrophages and cardiac resident macrophages during cardiac injury. Although experimental evidence shows promise for macrophage-targeted therapy in cardiomyopathy, clinical translation remains challenging. In this article, the molecular mechanism of macrophages in cardiomyopathy is discussed in detail in combination with the literature, and the issues and considerations of clinical treatment strategies for myocardial fibrosis are analyzed.