AUTHOR=Qian Benheng , Wu Kui , Lou Xiaoying , Li kexin , Wu Lianpin , Zhang Donghong 

TITLE=Ferroptosis Associates With Diagnosis and Prognosis by Promoting Antitumor Immune Response in Melanoma

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.915198

DOI=10.3389/fcell.2022.915198

ISSN=2296-634X

ABSTRACT=Immunotherapy has greatly improved the clinical benefits of cancer treatment, especially in melanoma. Ferroptosis is a new mechanism of cancer cell death and relates to immunity. This study aimed at understanding the potential link between ferroptosis and cancer immunocompetent in melanoma using multiple bioinformatics analyses. By WGCNA assay, we firstly constructed a key module-gene of ferroptosis, which was strongly correlated with the diagnosis, prognosis, and infiltration of immune cells in melanoma. Elevated module-gene could effectively distinguish melanoma from normal tissues and acted as a good prognostic marker. The module-gene of ferroptosis was positively correlated with the infiltration of immune cells. Especially, the module was positively correlated with the PD-L1 mRNA expression and sensitively increased after the effective anti-PD1 treatment. Furthermore, a similar correlation of the module-gene with infiltration of immune cells and the expression of PD-L1 was confirmed at the pan-cancer level. The differential expression of the module-gene in pan-cancer was dependent on the status of immunity. Our study demonstrated that the key module-gene of ferroptosis was involved in diagnosis, prognosis, and anti-immune response in melanoma, as well in pan-cancer.