AUTHOR=Karthic Anandakrishnan , Roy Arpita , Lakkakula Jaya , Alghamdi Saad , Shakoori Afnan , Babalghith Ahmad O. , Emran Talha Bin , Sharma Rohit , Lima Clara Mariana Gonçalves , Kim Bonglee , Park Moon Nyeo , Safi Sher Zaman , de Almeida Ray Silva , Coutinho Henrique Douglas Melo 

TITLE=Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.984311

DOI=10.3389/fcell.2022.984311

ISSN=2296-634X

ABSTRACT=Cancer is still one of the world’s deadliest health concern. As per latest statistics: lung, breast, liver, prostate and cervical cancers are reported topmost worldwide. Although chemotherapy is most widely used methodology to treat cancer, poor pharmacokietic parameters of anticancer drugs render them less effective. Novel nano-drug delivery systems has the caliber to improve the solubility and biocompatibility of various chemical compounds. In this regard cyclodextrins (CD), a group of natural nano-oligosaccharide possessing unique physicochemical characteristics has been highly exploited for drug delivery and other pharmaceutical purposes. Their cup-like structure and amphiphilic nature allows better accumulation of drugs, improved solubility and stability. Whereas its supramolecular chemical compatibility renders it highly receptive to various kinds of functionalization. Therefore combining physical, chemical and bio-engineering approaches at nanoscale to specifically target the tumour cells can help in maximizing the tumour damage without harming non-malignant cells. Numerous combinations of CD nanocomposites were developed over the years which employed photodynamic, photothermal therapy, chemotherapy and hyperthermia methods specifically against cancer cells. In this review we discuss the vivid roles of cyclodextrin nanocomposites developed for the treatment and theranostics of most important cancers to highlight its clinical significance and potential as a medical tool.