AUTHOR=Sarmah Hemanta , Sawada Anri , Hwang Youngmin , Miura Akihiro , Shimamura Yuko , Tanaka Junichi , Yamada Kazuhiko , Mori Munemasa 

TITLE=Towards human organ generation using interspecies blastocyst complementation: Challenges and perspectives for therapy

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1070560

DOI=10.3389/fcell.2023.1070560

ISSN=2296-634X

ABSTRACT=<p>Millions of people suffer from end-stage refractory diseases. The ideal treatment option for terminally ill patients is organ transplantation. However, donor organs are in absolute shortage, and sadly, most patients die while waiting for a donor organ. To date, no technology has achieved long-term sustainable patient-derived organ generation. In this regard, emerging technologies of chimeric human organ production <italic>via</italic> blastocyst complementation (BC) holds great promise. To take human organ generation <italic>via</italic> BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology.</p>