AUTHOR=Yu Xue , Yang Yan , Chen Tianzuo , Wang Yuqin , Guo Tianwei , Liu Yujun , Li Hong , Yang Liming 

TITLE=Cell death regulation in myocardial toxicity induced by antineoplastic drugs

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1075917

DOI=10.3389/fcell.2023.1075917

ISSN=2296-634X

ABSTRACT=In recent years, significant progress has been made in the development of new cancer therapies that have greatly improved patient survival, but may also lead to serious cardiac adverse effects. The mechanisms by which antineoplastic drugs cause cardiomyocyte death remain unknown. This article presents recent advances in antineoplastic drug-induced regulatory cardiomyocyte death pathways, including autophagy, ferroptosis, apoptosis, pyroptosis, and necroptosis. Mitochondria are key organelles for maintaining homeostasis in myocardial tissue, and this article focuses on the importance of mitochondrial homeostasis in cardiotoxicity.