AUTHOR=Zhang Huhu , Zhang Zhe , Guo Tingting , Chen Guang , Liu Guoxiang , Song Qinghang , Li Guichun , Xu Fenghua , Dong Xiaolei , Yang Fanghao , Cao Can , Zhong Di , Li Shuang , Li Ya , Wang Mengjun , Li Bing , Yang Lina TITLE=Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=Volume 11 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1141331 DOI=10.3389/fcell.2023.1141331 ISSN=2296-634X ABSTRACT=

The annexin A (ANXA) protein family is a well-known tissue-specific multigene family that encodes Ca2+ phospholipid-binding proteins. A considerable amount of literature is available on the abnormal expression of ANXA proteins in various malignant diseases, including cancer, atherosclerosis and diabetes. As critical regulatory molecules in cancer, ANXA proteins play an essential role in cancer progression, proliferation, invasion and metastasis. Recent studies about their structure, biological properties and functions in different types of cancers are briefly summarised in this review. We further discuss the use of ANXA as new class of targets in the clinical diagnosis and treatment of cancer.