AUTHOR=Dong Jia-Mei , Wang Rui-Qi , Yuan Ning-Ning , Guo Jia-Hao , Yu Xin-Yang , Peng Ang-Hui , Cai Jia-Yi , Xue Lei , Zhou Zhi-Ling , Sun Yi-Hao , Chen Ying-Yin 

TITLE=Recent advances in optical aptasensors for biomarkers in early diagnosis and prognosis monitoring of hepatocellular carcinoma

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1160544

DOI=10.3389/fcell.2023.1160544

ISSN=2296-634X

ABSTRACT=Hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancers and is one of the main malignant tumor types worldwide. It is essential to develop rapid, ultrasensi-tive, and accurate strategies for diagnosis and surveillance of HCC. In recent years, aptasensors have attracted particular attention owing to their high sensitivity, excellent selectivity, and low production costs. Optical analysis, as a potential analytical tool, has the advantages of a wide range of targets, rapid response, and simple instrumentation. In this review, recent progresses in several kinds of optical aptasensors for biomarkers in early diagnosis and prognosis monitoring of HCC were summarized. Furthermore, we evaluated the strengths and limitations of these sensors and discussed the challenges and future perspectives for their use in HCC diagnosi and surveil-lance.