AUTHOR=Zhang Kaiqiang , Lu Zhenfu , Guo Xiaoying 

TITLE=Advances in epidemiological status and pathogenesis of dental fluorosis

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1168215

DOI=10.3389/fcell.2023.1168215

ISSN=2296-634X

ABSTRACT=Fluoride is commonly considered a “double-edged sword” because low consumption of fluoride can effectively prevent dental caries, but excessive consumption of fluoride can cause fluorosis. Dental fluorosis (DF) is acharacteristic of fluorosis in the oral cavity that is manifested as tooth color change and evident enamel defect. Presently, the pathogenesis of DF remains unclear. Herein, we have summarized the research progress on the pathogenesis and mechanism of DF in the past 5 years.